Water → 5-t-Butyl-3-cyclobutanecarbonylaminopyrazole

HRID 2164503

Reaktionsgleichung

Reaktionsgleichung von HRID 2164503
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[NH:4][N:3]=1.C(N(CC)CC)C.[CH:18]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19]1.O>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[C:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:22]([CH:18]2[CH2:21][CH2:20][CH2:19]2)=[O:23])[CH:6]=1)([CH3:10])([CH3:9])[CH3:8]

Komponenten

7

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 5227873-Amino-5-tert-butylpyrazole

Produkt 1

HCID 134770005-t-Butyl-3-cyclobutanecarbonylaminopyrazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 5943Carbon TetrachlorideLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4.3 g (0.03 mole) of 3-amino-5-t-butylpyrazole as prepared in Example 1 and 3 g of triethylamine were dissolved in 30 ml of methylene chloride. To this solution was added dropwise 3.6 g of cyclobutanecarboxylic acid chloride dissolved in 30 ml of carbon tetrachloride. The resulting mixture was allowed to stand at room temperature over night. Thereafter, water was added thereto followed by shaking it. Crystals thus formed were collected by filtration and washed with water and carbon tetrachloride to obtain 5-t-butyl-3-cyclobutanecarbonylaminopyrazole.

Aufarbeitung

  1. waitto stand at room temperature over night
  2. customCrystals thus formed
  3. filtrationwere collected by filtration
  4. washwashed with water and carbon tetrachloride

Quellen und Nachweise

ORD-Eintrag
ord-7b86865510af4e1e9851b0c31e5ea268
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04505739

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