Hydrochloric Acid → 6-Allyloxybenzothiazole-2-sulfonamide

HRID 2164615Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2164615
CN(C)C=[N:4][S:5]([C:8]1[S:9][C:10]2[CH:16]=[C:15]([O:17][CH2:18][CH:19]=[CH2:20])[CH:14]=[CH:13][C:11]=2[N:12]=1)(=[O:7])=[O:6].[OH-].[Na+].O.Cl>CO>[CH2:18]([O:17][C:15]1[CH:14]=[CH:13][C:11]2[N:12]=[C:8]([S:5]([NH2:4])(=[O:7])=[O:6])[S:9][C:10]=2[CH:16]=1)[CH:19]=[CH2:20]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 53647804N,N-Dimethyl-N'-(6-allyloxybenzothiazole-2-sulfonyl)formamidine

Produkt 1

HCID 134732046-Allyloxybenzothiazole-2-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A solution of product from Step B (0.45 gm, 1.4 mmol) in methanol (1.5 mL) was added to 2N sodium hydroxide (2 mL) and stirred at 40° C. for 1 hour. The reaction was poured into water, acidified (HCl), and the product extracted into ethyl acetate. The extract was dried (Na2SO4) and evaporated to give crude product. Upon trituration of this residue with methylene chloride, the product precipitated and was collected (0.18 gm) and shown to be identical with the product of Example 1.

Aufarbeitung

  1. extractionthe product extracted into ethyl acetate
  2. dry with materialThe extract was dried (Na2SO4)
  3. customevaporated
  4. customto give crude product
  5. customUpon trituration of this residue with methylene chloride, the product precipitated
  6. customwas collected (0.18 gm)

Quellen und Nachweise

ORD-Eintrag
ord-5581e90325654ed8a600846d876b58ed
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04505923

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