benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate → O-acetoacetyl-N-trifloroacetyl-L-serine

HRID 2165229Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2165229
[C:1]([O:7][CH2:8][C@@H:9]([C:17]([O:19]CC1C=CC=CC=1)=[O:18])[NH:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]>[Pd].C(O)C>[C:1]([O:7][CH2:8][C@@H:9]([C:17]([OH:19])=[O:18])[NH:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4]

Komponenten

4

Edukt 1

HCID 53948101benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate

Produkt 1

HCID 18640001O-acetoacetyl-N-trifloroacetyl-L-serineAusbeute 95,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of benzyl O-acetoacetyl-N-trifluoroacetyl-L-serinate (320 mg) and 10% palladium on activated carbon (40 mg) in ethanol (10 ml) was hydrogenated under hydrogen at one atom for 20 minutes. The mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals) and the filtrate was concentrated to give O-acetoacetyl-N-trifloroacetyl-L-serine (232 mg).

Aufarbeitung

  1. filtrationThe mixture was filtered with Celite (filter aid, trade mark, made by Nakarai Chemicals)
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-4c02b58b79d64e88a2ff0a6eecbabd51
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04939241

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