Sodium Hydroxide → HCID 18640048, Verbindung

HRID 2165250Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2165250
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH2:11][C@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@H:13]1[C@@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 86744074platinum (II) potassium chlorideHCID 86744075HCID 86744075, Verbindung

Produkt 1

HCID 18640048HCID 18640048, VerbindungAusbeute 63,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

(3S)-3-Aminopyrrolidine L(+)-tartrate (236 mg) prepared in Reference Example 1-(2) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated to dryness under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3S)-3-aminopyrrolidine platinum (II) (221 mg) as pale yellow crystal.

Aufarbeitung

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated to dryness under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

Quellen und Nachweise

ORD-Eintrag
ord-2f929b10abdf44e88701b4098c6aaa5a
Quelldatensatz
uspto-grants-1990_07
Patentnummer
US04939256

Notizen zur Reaktion

Wird geladen…