Acetic Anhydride → HCID 14835102, Verbindung
Reaktionsgleichung
[C:1]([CH:3]1[C:12](=[O:13])[N:11]2[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]2)=[C:5]2[C:14]([CH2:17][CH2:18][CH3:19])=[N:15][N:16]=[C:4]12)#[N:2].[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([N:16]1[C:4]2=[C:3]([C:1]#[N:2])[C:12](=[O:13])[N:11]3[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]3)=[C:5]2[C:14]([CH2:17][CH2:18][CH3:19])=[N:15]1)(=[O:22])[CH3:21]Komponenten
3
Versuchsvorschrift
A mixture of 80 g of 4-cyano-1-propyl-5H-pyrazolo-[4,3-a]quinolizin-5-one (S-1) and 2.0 l of acetic anhydride was heated under reflux for 18 hours. The solvent was evapolated under reduced pressure and the residual crystals were washed with water (0.5 l), methyl alcohol (0.5 l) and chloroform (0.5 l) successively to give 84 g of 3-acetyl-4-cyano-1-propyl-5H-pyrazolo-[4,3-a]quinolizin-5-one as pale yellow crystals.
Aufarbeitung
- temperaturewas heated
- temperatureunder reflux for 18 hours
- washthe residual crystals were washed with water (0.5 l), methyl alcohol (0.5 l) and chloroform (0.5 l) successively