Ethanol → 4-p-Tolylsulfonyl-4-methyl-3-dimethoxymethyl-pentanoic acid

HRID 2166957

Reaktionsgleichung

Reaktionsgleichung von HRID 2166957
[C:1]1([CH3:24])[CH:6]=[CH:5][C:4]([S:7]([C:10]([CH3:23])([CH3:22])[CH:11]([CH:17]([O:20][CH3:21])[O:18][CH3:19])[CH2:12][C:13]([O:15]C)=[O:14])(=[O:9])=[O:8])=[CH:3][CH:2]=1.C(O)C.[OH-].[Na+]>O>[C:1]1([CH3:24])[CH:6]=[CH:5][C:4]([S:7]([C:10]([CH3:22])([CH3:23])[CH:11]([CH:17]([O:18][CH3:19])[O:20][CH3:21])[CH2:12][C:13]([OH:15])=[O:14])(=[O:9])=[O:8])=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 12850320Methyl 4-p-tolylsulfonyl-4-methyl-3-dimethoxymethylpentanoate

Produkt 1

HCID 128503174-p-Tolylsulfonyl-4-methyl-3-dimethoxymethyl-pentanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1 g of the product of Step A was added to a mixture of 20 ml of ethanol and 20 ml of aqueous 2 N sodium hydroxide solution and the mixture was refluxed for 17 hours and was cooled and poured into water. The mixture was extracted with methylene chloride and the organic phase was evaporated to dryness to obtain 4-p-tolylsulfonyl-4-methyl-3-dimethoxymethyl-pentanoic acid.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 17 hours
  2. temperaturewas cooled
  3. extractionThe mixture was extracted with methylene chloride
  4. customthe organic phase was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-1f8589769f9842c4948589fc9c8644e6
Quelldatensatz
uspto-grants-1983_06
Patentnummer
US04390724

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