Diisopropylethylamine → HCID 71075406, Verbindung

HRID 2170628Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170628
[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:26]=[CH:25][C:9]([CH2:10][N:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20](O)=[O:21])=[CH:17][CH:18]=3)[C:13]([CH3:23])=[C:12]2[CH3:24])=[CH:8][CH:7]=1.Cl.[CH:29]1([C:32]2[CH:33]=[C:34]([C@@H:38]([NH2:40])[CH3:39])[CH:35]=[CH:36][CH:37]=2)[CH2:31][CH2:30]1.CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C(Cl)Cl.C(OCC)(=O)C>[CH:29]1([C:32]2[CH:33]=[C:34]([C@@H:38]([NH:40][C:20]([C:16]3[CH:15]=[C:14]4[C:19](=[CH:18][CH:17]=3)[N:11]([CH2:10][C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([O:2][CH3:1])=[O:27])=[CH:26][CH:25]=3)[C:12]([CH3:24])=[C:13]4[CH3:23])=[O:21])[CH3:39])[CH:35]=[CH:36][CH:37]=2)[CH2:31][CH2:30]1

Komponenten

7

Edukt 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 71075337HCID 71075337, VerbindungHCID 86674582HCID 86674582, Verbindung

Produkt 1

HCID 71075406HCID 71075406, VerbindungAusbeute 102,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid (50 mg, 0.14 mmol) in DCM (1 mL) was added the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride (28 mg), DIEA (73 μL) and HATU (53 mg). The reaction mixture was allowed to stir at rt for 30 min, and then was diluted by ethyl acetate. The resulting mixture was washed with a 0.5 N HCl solution, a saturated solution of NaHCO3, and brine, dried on MgSO4, and concentrated to afford a yellow oil (73 mg) which was directly used without further purification. ESI-MS (m/z): 497 [M+H]+

Aufarbeitung

  1. washThe resulting mixture was washed with a 0.5 N HCl solution
  2. dry with materiala saturated solution of NaHCO3, and brine, dried on MgSO4
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-635ec30f66e24bb89e15eace0a5c1027
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051265B2

Notizen zur Reaktion

Wird geladen…