Morpholine → HCID 71075333, Verbindung

HRID 2170718Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170718
[C:1]([C:3]1([C:6]2[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=2)[CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([O:21]CC=C)=[O:20])=[CH:16][CH:17]=3)[C:12]([CH3:25])=[C:11]2[CH3:26])[CH2:5][CH2:4]1)#[N:2].N1CCOCC1>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]([C:3]1([C:6]2[CH:7]=[C:8]([CH:27]=[CH:28][CH:29]=2)[CH2:9][N:10]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([OH:21])=[O:20])=[CH:16][CH:17]=3)[C:12]([CH3:25])=[C:11]2[CH3:26])[CH2:4][CH2:5]1)#[N:2]

Komponenten

5

Edukt 2

HCID 8083MorpholineHCID 86674597HCID 86674597, Verbindung

Produkt 1

HCID 71075333HCID 71075333, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The mixture of allyl 1-(3-(1-cyanocyclopropyl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (375 mg, 0.98 mmol) and morpholine (0.8 mL, 9.2 mmol) in THF (8 mL) was degassed and then Pd(PPh3)4 (117 mg, 0.10 mmol) was added. The mixture was stirred at room temperature for 1 h. The solvent was removed and the residue was dissolved in Methanol and acidified to pH 4. The precipitate was collected and washed with water to obtain the title compound.

Aufarbeitung

  1. customwas degassed
  2. customThe solvent was removed
  3. dissolutionthe residue was dissolved in Methanol
  4. customThe precipitate was collected
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-8b5f423b20cb43888807304be023fde7
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051265B2

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