Morpholine → HCID 71075457, Verbindung

HRID 2170721Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170721
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:26]=[CH:27][CH:28]=1)[CH2:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([O:20]CC=C)=[O:19])=[CH:15][CH:16]=2)[C:11]([CH3:24])=[C:10]1[CH3:25])=[O:4].N1CCOCC1>C1COCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:26]=[CH:27][CH:28]=1)[CH2:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[C:11]([CH3:24])=[C:10]1[CH3:25])=[O:4]

Komponenten

5

Edukt 2

HCID 8083MorpholineHCID 86674599HCID 86674599, Verbindung

Produkt 1

HCID 71075457HCID 71075457, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The mixture of allyl 1-(3-(methoxycarbonyl)benzyl)-2,3-dimethyl-1H-indole-5-carboxylate (133 mg, 0.35 mmol) and morpholine (0.3 mL, 3.4 mmol) in THF (4 mL) was degassed and then Pd(PPh3)4 (41 mg, 0.035 mmol) was added. The mixture was stirred at room temperature for 1 h. The solvent was removed and the residue was dissolved in Methanol and acidified to pH 4. The precipitate was collected and washed with water to obtain the title compound.

Aufarbeitung

  1. customwas degassed
  2. customThe solvent was removed
  3. dissolutionthe residue was dissolved in Methanol
  4. customThe precipitate was collected
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-783ca35ee8a24193b06e89f7523cbedf
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09051265B2

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