Iodine → 2,4-dichloro-5-iodobenzoic acid

HRID 217283

Reaktionsgleichung

Reaktionsgleichung von HRID 217283
I([O-])(=O)=O.[Na+].[I:6]I.[Cl:8][C:9]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]>S(=O)(=O)(O)O>[Cl:8][C:9]1[CH:17]=[C:16]([Cl:18])[C:15]([I:6])=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]

Komponenten

5

Edukt 3

HCID 807IodineHCID 57872,4-Dichlorobenzoic AcidHCID 23675764Sodium Iodate

Produkt 1

HCID 684179092,4-dichloro-5-iodobenzoic acidAusbeute 121,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

Sodium iodate (4.4 g) and iodine (11.1 g) were added to 90% sulfuric acid (330 mL), and stirred at room temperature for 8 hours. 2,4-Dichlorobenzoic acid (21 g) commercially available was added and stirred at the same temperature for 24 hours. The reaction solution was poured into ice water (3 L), and the precipitated solid material was collected by filtration. Further, the solid material was washed with water, and dried under reduced pressure. 2,4-Dichloro-5-iodobenzoic acid (16.8 g) was obtained by recrystallization (acetic acid-water). The resulting 2,4-dichloro-5-iodobenzoic acid (2 g) was dissolved in a mixture of dichloromethane (20 mL) and methanol (20 mL). Trimethylsilyldiazomethane (hexane solution, 2 M) was added dropwise until the solution became yellow. A small amount of acetic acid was added, and then the resulting mixture was concentrated under reduced pressure. The resulting residue was recrystallized using hexane to give the title compound 2,4-dichloro-5-iodobenzoic acid methyl ester as white solid (2 g).

Aufarbeitung

  1. stirringstirred at the same temperature for 24 hours
  2. filtrationthe precipitated solid material was collected by filtration
  3. washFurther, the solid material was washed with water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-462cf85cee2c4c528734f47e9d42eaf1
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193351B2

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