Carbamimidoyl-nitroso-acetic acid ethyl ester → HCID 12439913, Verbindung
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:11])[CH:5]([C:8](=[NH:10])[NH2:9])[N:6]=O)[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:11])[CH:5]([NH2:6])[C:8](=[NH:9])[NH2:10])[CH3:2]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of carbamimidoyl-nitroso-acetic acid ethyl ester (5.5 g, 31.4 mmol) in ethanol/5M HCl (1:1 ratio, 250 ml) was added 10% Pd/C (1.3 g). The reaction mixture was hydrogenated (H2(g)) at low pressure over 2 nights. The Pd/C was filtered through Celite® (filter material) and the filtrate reduced in vacuo to give the title compound as a white solid. This was taken through to the next step as crude.
Aufarbeitung
- customover 2 nights
- filtrationThe Pd/C was filtered through Celite® (filter material)
Quellen und Nachweise
- ORD-Eintrag
- ord-c87fdd40e35c405fb44c69f20b90eac7
- Quelldatensatz
- uspto-grants-2015_06
- Patentnummer
- US09056867B2
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