Water → 3-Bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amine

HRID 2174654Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2174654
C1C(=O)N([Br:8])C(=O)C1.[CH3:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]=[CH:21][C:22]([NH2:25])=[N:23][CH:24]=2)=[CH:15][CH:14]=1)(=[O:12])=[O:11].O>CN(C=O)C>[Br:8][C:21]1[C:22]([NH2:25])=[N:23][CH:24]=[C:19]([C:16]2[CH:15]=[CH:14][C:13]([S:10]([CH3:9])(=[O:11])=[O:12])=[CH:18][CH:17]=2)[N:20]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 580843845-[4-(Methylsulfonyl)phenyl]-2-pyrazinamine

Produkt 1

HCID 580843703-Bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amineAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

NBS (1.807 g, 10.15 mmol) was added to a stirred solution of 5-(4-methylsulfonylphenyl)pyrazin-2-amine (2.53 g, 10.15 mmol) in DMF (40 mL) and the reaction stirred at ambient temperature for 15 hours. The reaction mixture was added slowly to rapidly stirring water and the resultant precipitate was isolated by filtration and dried in vacuo to give the sub-title compound as a beige solid that was used without further purification (2.8 g, 84% Yield).

Quellen und Nachweise

ORD-Eintrag
ord-a0da0d13b1674a2f8852c66c22ec0d2c
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062008B2

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