Hydrochloric Acid → 4,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid

HRID 2175177Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2175177
[CH3:1][C:2]1[C:7]2[C:8]([C:11](N)=[O:12])=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:14])[CH:3]=1.[OH-:15].[K+].Cl>CCO.O>[CH3:1][C:2]1[C:7]2[C:8]([C:11]([OH:15])=[O:12])=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:14])[CH:3]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 584974364,6-Dimethyl-1,2-benzisothiazole-3-carboxylic acid amide

Produkt 1

HCID 584973864,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

To a solution of 4,6-dimethyl-benzo[d]isothiazole-3-carboxylic acid amide (20 mg, 0.097 mmol) in EtOH (10 mL) and H2O (2 mL) was added KOH (11 mg, 0.19 mmol). The solution was heated to 85° C. for 48 hours. The solution was cooled and was placed in an ice bath. Conc. HCl was added to adjust the pH of the solution to 2. The solid that precipitated out from the solution was collected by filtration. The white solid was dried and was confirmed to be the title compound (15 mg, 75%).

Aufarbeitung

  1. temperatureThe solution was cooled
  2. customwas placed in an ice bath
  3. customThe solid that precipitated out from the solution
  4. filtrationwas collected by filtration
  5. customThe white solid was dried

Quellen und Nachweise

ORD-Eintrag
ord-c01df5994f6b44ff822cda85ad72a302
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09062056B2

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