Acetic Acid → Benzhydrol

HRID 217549

Reaktionsgleichung

Reaktionsgleichung von HRID 217549
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH4+].[Cl-].CC(O)=O>C1COCC1>[C:9]1([CH:1]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[OH:8])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 3102BenzophenoneHCID 25517Ammonium Chloride

Produkt 1

HCID 7037Benzhydrol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1 mmole (182 mg) of benzophenone dissolved in 5 mL THF was stirred with 0.5 g of 12% Li-AG and solid state proton sources such as NH4Cl, (NH4)2HPO4, or dropwise addition of glacial AcOH at room temperature after a deep blue colored solution is produced. The color of the reaction vessel gradually fades and becomes grey at the end indicating complete consumption of lithium. The reaction mixture was filtered, the solids washed with hexane, and the solvent was removed from the combined organic solutions under vacuum to obtain a white solid corresponding to diphenyl methanol as confirmed by 1H, 13C NMR and ESI-MS. See FIGS. 3A-3C.

Aufarbeitung

  1. customis produced
  2. customconsumption of lithium
  3. filtrationThe reaction mixture was filtered
  4. washthe solids washed with hexane
  5. customthe solvent was removed from the combined organic solutions under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fec6cb85a6e2434088d9a39ed31a0e85
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08197707B2

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