Potassium Carbonate → 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine

HRID 217691Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 217691
Br.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 866507946-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

Produkt 1

HCID 151078816-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amineAusbeute 30,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001; 1.1 g) was taken up with a large amount of water and alkalized with saturated potassium carbonate solution. The solid which precipitated out was filtered off with suction and dried (388 mg). Repeated extraction of the mother liquor with dichloromethane, drying of the combined organic phases over sodium sulfate, filtration and concentration afforded a further 228 mg of product in total.

Aufarbeitung

  1. customThe solid which precipitated out
  2. filtrationwas filtered off with suction
  3. customdried (388 mg)
  4. extractionextraction of the mother liquor with dichloromethane
  5. dry with materialdrying of the combined organic phases over sodium sulfate, filtration and concentration

Quellen und Nachweise

ORD-Eintrag
ord-3f4d53f273924bc791e4569682cc93f6
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198272B2

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