2-Methoxy-1-phenylethanone → 2-Methoxy-1-phenylethan-1-ol

HRID 2177059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2177059
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[CH3:1][O:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[OH:5]

Komponenten

4

Edukt 2

HCID 776982-Methoxy-1-phenylethanoneHCID 4311764Sodium borohydride

Produkt 1

HCID 5722942-Methoxy-1-phenylethan-1-olAusbeute 78,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 2-methoxy-1-phenylethanone (1.0 g, 6.66 mmol) in ethanol was added sodium borohydride (0.28 g, 7.32 mmol). The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was quenched with sat. ammonium chloride solution, concentrated. Extracted with ethyl acetate, washed with brine, dried, and concentrated to yield 0.8 g of 2-methoxy-1-phenylethanol.

Aufarbeitung

  1. customThe reaction mixture was quenched with sat. ammonium chloride solution
  2. concentrationconcentrated
  3. extractionExtracted with ethyl acetate
  4. washwashed with brine
  5. customdried
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-319bf6ac8f264037b5baa63ae110b16d
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09067897B2

Notizen zur Reaktion

Wird geladen…