Water → Methyl 3-methoxy-5-(trifluoromethyl)benzoate

HRID 217748Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 217748
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5](O)=[O:6].CI.[C:17](=O)([O-])[O-].[K+].[K+].O.CN([CH:27]=[O:28])C>>[CH3:17][O:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([O:28][CH3:27])=[O:6]

Komponenten

6

Edukt 5

HCID 962WaterHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27831463-hydroxy-5-(trifluoromethyl)benzoic Acid

Produkt 1

HCID 46311161Methyl 3-methoxy-5-(trifluoromethyl)benzoate

Versuchsvorschrift

3-Hydroxy-5-trifluoromethylbenzoic acid (2 g) was initially charged at RT in DMF (15 ml) while stirring, and admixed dropwise with methyl iodide (3.0 ml). After adding potassium carbonate (5.6 g), the mixture was stirred for 5 h and left to stand overnight. It was then admixed with water and extracted three times with MtB ether. The combined MTB ether phases were dried over sodium sulfate, filtered and concentrated. 2.29 g of the title compound were obtained.

Aufarbeitung

  1. stirringthe mixture was stirred for 5 h
  2. waitleft
  3. extractionextracted three times with MtB ether
  4. dry with materialThe combined MTB ether phases were dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6ec8dcf9d8e141738b0b38ed3d53305f
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198272B2

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