Thiophenol → Methyl 5-bromo-2-(phenylthiomethyl)benzoate

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Reaktionsgleichung

BrC1C(OC)=C(C=CC=1C[S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1C)C(OCC)=O.[Br:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:35]Br)=[C:29]([CH:34]=1)[C:30]([O:32][CH3:33])=[O:31].C1(S)C=CC=CC=1>>[Br:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:35][S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:29]([CH:34]=1)[C:30]([O:32][CH3:33])=[O:31]

Komponenten

Edukt 3

HCID 7969Thiophenol

HCID 12929136Methyl 5-bromo-2-(bromomethyl)benzoate

HCID 67107587Ethyl 3-bromo-2-methoxy-(2-methylphenylthiomethyl)benzoate

Produkt 1

HCID 67107602Methyl 5-bromo-2-(phenylthiomethyl)benzoate

Versuchsvorschrift

Prepared by proceeding in a similar manner to Intermediate 77, starting from methyl 5-bromo-2-bromomethylbenzoate (prepared according to Lartia et al, J Org Chem, 2008, 73, 1732) and thiophenol.

Aufarbeitung

customPrepared

Quellen und Nachweise

ORD-Eintrag: ord-fade0985a8f845f8b3dde24095ff2041
Quelldatensatz: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09067905B2

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