Diethyl Oxalate → 8-(4-aminophenoxy)pyrido[2,3-b]pyrazine-2,3(1H,4H)-dione
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16]C(=O)OC(C)(C)C)=[CH:12][CH:11]=2)[CH:5]=[CH:4][N:3]=1.[C:24](OCC)(=[O:30])[C:25](OCC)=[O:26]>>[NH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][C:6]2[C:7]3[NH:8][C:25](=[O:26])[C:24](=[O:30])[NH:1][C:2]=3[N:3]=[CH:4][CH:5]=2)=[CH:15][CH:14]=1Komponenten
3
Versuchsvorschrift
A solution of tert-butyl 4-(2,3-diamino pyridin-4-yloxy)phenylcarbamate (0.320 g, 1.0 mmol) in diethyl oxalate (2 ml) is reacted twice for 10 minutes in a microwave reactor (180 C, 150 W). The solution is cooled and the solid filtered and washed with cold ethanol. Obtained 8-(4-aminophenoxy)pyrido[2,3-b]pyrazine-2,3(1H,4H)-dione (70 mg, 25% yield) as a grey solid.
Aufarbeitung
- temperatureThe solution is cooled
- filtrationthe solid filtered