HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Chloro-2-fluoro-5-hydroxypyridine → 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-3-cyano-N-(5-fluoropyridin-2-yl)benzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Chloro-2-fluoro-5-hydroxypyridine | HCID 22451555 | — |
| Edukt | 3-cyano-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide | HCID 59436600 | — |
| Produkt | 4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-3-cyano-N-(5-fluoropyridin-2-yl)benzenesulfonamide | HCID 117653188 | — |
Reaktionsschritte
The title compound was prepared according to the method described for Method Variation 1 using 3-cyano-4-fluoro-N-(5-fluoropyridin-2-yl)benzenesulfonamide (Preparation 2) and 3-chloro-2-fluoro-5-hydroxypyridine and then purified using silica gel column chromatography eluting with 30-35% EtOAc in heptanes.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09067922B2 |
| Quelldatensatz | uspto-grants-2015_06 |
| ORD ID | ord-5e427315feae431dbc92cb1f7437f91f |
| Quellennotiz | uspto-grants-2015_06 |