3-(2-Bromo-5-(trifluoromethyl)phenyl)propanoic acid → 5-(Trifluoromethyl)indan-1-one

HRID 2178767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2178767
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[CH2:12][CH2:13][C:14]([OH:16])=O.C([Li])CCC>C1COCC1.CCCCCC>[F:11][C:8]([F:9])([F:10])[C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[C:14](=[O:16])[CH2:13][CH2:12]2

Komponenten

5

Edukt 2

HCID 248204723-(2-Bromo-5-(trifluoromethyl)phenyl)propanoic acidHCID 178418339Butyllithium

Produkt 1

HCID 121749875-(Trifluoromethyl)indan-1-oneAusbeute 37,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8058HexaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3-[2-bromo-5-(trifluoromethyl)phenyl]propanoic acid (2.8 g, 9.4 mmol) in THF (100 mL) and hexane (20 mL) at −78° C. was dropwise added a 2.5 M solution of n-butyllithium in hexane (8.3 mL). After the addition had been completed, the reaction was quenched with saturated NH4Cl. The resulting solution was extracted with ethyl acetate twice. The extracts were washed with saturated NaHCO3, brine, dried over MgSO4 and concentrated. The crude material was purified by flash chromatography on silica eluting with 10-20% EtOAc/hexane to afford the desired product as a white solid (0.7 g, 37%). LC/MS calculated for C10H7F3O: (M+H)+201; found 201.1.

Aufarbeitung

  1. additionAfter the addition
  2. customthe reaction was quenched with saturated NH4Cl
  3. extractionThe resulting solution was extracted with ethyl acetate twice
  4. washThe extracts were washed with saturated NaHCO3, brine
  5. dry with materialdried over MgSO4
  6. concentrationconcentrated
  7. customThe crude material was purified by flash chromatography on silica eluting with 10-20% EtOAc/hexane

Quellen und Nachweise

ORD-Eintrag
ord-7ee87631dd1b462fae217e6b48e9ebc2
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09067921B2

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