Sodium Hydroxide → HCID 69794736, Verbindung

HRID 2181667Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2181667
[C:1]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([O:15]C)=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2].[OH-].[Na+]>CO.O>[C:1]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 22481734HCID 22481734, Verbindung

Produkt 1

HCID 69794736HCID 69794736, VerbindungAusbeute 93.124,703 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Methyl 2-acetyl-1-benzofuran-6-carboxylate (155 mg, 0.71 mmol) is dissolved in MeOH (3 ml) and H2O (0.5 ml). 2N NaOH (0.39 ml, 0.78 mmol) is added drop-wise, and the reaction is stirred overnight. The volatiles are removed in vacuo, and the residue is dissolved in H2O (3 ml). Concentrated HCl is used to adjust the pH to 3, and the resulting precipitate is isolated via filtration and dried overnight to afford 135 g (93%) of 2-acetyl-1-benzofuran-6-carboxylic acid as a yellow solid. MS for C11H8O4, (ESI−) m/z: 202.7 (M−H)−.

Aufarbeitung

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe residue is dissolved in H2O (3 ml)
  3. customthe resulting precipitate is isolated via filtration
  4. customdried overnight

Quellen und Nachweise

ORD-Eintrag
ord-88965b41741748a798df5bed403c52cc
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06894042B2

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