Ammonium Acetate → 1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181908

Reaktionsgleichung

Reaktionsgleichung von HRID 2181908
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

Komponenten

5

Edukt 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823721-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

Produkt 1

HCID 224823821-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The title compound was prepared from 1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (720 mg, 2.9 mmol), anhydrous methanol (10 mL), ammonium acetate (4.44 g, 58 mmol), and sodium cyanoborohydride (362 g, 5.8 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 114, step c;

Aufarbeitung

  1. customThe crude amine was immediately used without further purification in Example 114, step c

Quellen und Nachweise

ORD-Eintrag
ord-aedbfb1c67b5452db02693817d12d88e
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06894061B2

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