Ammonium Acetate → HCID 22482279, Verbindung

HRID 2181915

Reaktionsgleichung

Reaktionsgleichung von HRID 2181915
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

Komponenten

5

Edukt 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224822741-(2',5',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

Produkt 1

HCID 22482279HCID 22482279, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The title compound was prepared from 1-(2′,5′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (650 mg, 2.6 mmol), anhydrous methanol (10 mL), ammonium acetate (4.0 g, 52 mmol), and sodium cyanoborohydride (326 g, 5.2 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 116, step c;

Aufarbeitung

  1. customThe crude amine was immediately used without further purification in Example 116, step c

Quellen und Nachweise

ORD-Eintrag
ord-85d4257011ad4af6afb5dfc5e879095a
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06894061B2

Verknüpfte Notizen

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