Hydrogen Bromide → Benzaldehyde, 2,3-dihydroxy-4-nitro-

HRID 218271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 218271
C([O:4][C:5]1[C:12]([O:13]C)=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])(=O)C.Br>C(O)(=O)C>[OH:4][C:5]1[C:12]([OH:13])=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=[CH:9][C:6]=1[CH:7]=[O:8]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 21783433HCID 21783433, Verbindung

Produkt 1

HCID 10442360Benzaldehyde, 2,3-dihydroxy-4-nitro-Ausbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

43 (2.5 g, 10.5 mmol) was added to a solution of acetic acid (62.5 mL) and hydrobromic acid 48% (70 mL) and the reaction mixture was heated at 150° C. for 4 h. The reaction mixture was then cooled to rt and evaporated to dryness. The residue was diluted in hot CH2Cl2 (40 mL) and filtered. The filtrate was evaporated to dryness to give 44 (1.74 g, 91%) which was used as such in the next step:

Aufarbeitung

  1. temperatureThe reaction mixture was then cooled to rt
  2. customevaporated to dryness
  3. additionThe residue was diluted in hot CH2Cl2 (40 mL)
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-ff0c615cad7d4dd096e5f930998f45a0
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198302B2

Notizen zur Reaktion

Wird geladen…