Ethanol → HCID 22474170, Verbindung

HRID 2183632Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2183632
[S:1]1[C:5]([C:6](=O)[CH2:7][Br:8])=[CH:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2.[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[BrH:8].[S:1]1[C:5]([C:6]2[N:16]3[CH2:17][CH2:18][N:14]=[C:15]3[S:19][CH:7]=2)=[CH:4][C:3]2[CH:10]=[CH:11][CH:12]=[CH:13][C:2]1=2

Komponenten

5

Edukt 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 27952581-(1-Benzothiophen-2-yl)-2-bromoethan-1-one

Produkt 1

HCID 22474170HCID 22474170, VerbindungAusbeute 75,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of 1-(benzo[b]thiophen-2-yl)-2-bromoethan-1-one (21.96 g), 2-imidazolidinethione (7.81 g) and ethanol (300 ml) was heated under reflux for 10 minutes. Acetic acid (150 ml) was added, then the mixture was heated under reflux for 18 hours and allowed to cool to ambient temperature. The resulting solid was collected by filtration, washed with ethanol (50 ml) and ether (50 ml), then dried in vacuo at 100° C. for 3 hours to give 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (19.6 g) as a light brown solid, m.p. 275-285° C. (decomposes).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 10 minutes
  3. temperaturethe mixture was heated
  4. temperatureunder reflux for 18 hours
  5. filtrationThe resulting solid was collected by filtration
  6. washwashed with ethanol (50 ml) and ether (50 ml)
  7. customdried in vacuo at 100° C. for 3 hours

Quellen und Nachweise

ORD-Eintrag
ord-3b12617c00734856bfe4e0e0734ef99f
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06900216B2

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