Sodium Carbonate → HCID 9943990, Verbindung

HRID 2183633Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2183633
C(=O)([O-])[O-].[Na+].[Na+].Br.[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2>ClCCl.O>[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2

Komponenten

5

Edukt 2

HCID 10340Sodium CarbonateHCID 22474170HCID 22474170, Verbindung

Produkt 1

HCID 9943990HCID 9943990, VerbindungAusbeute 90,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Sodium carbonate (9.29 g) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (19.0 g) in a mixture of dichloromethane (300 ml) and water (300 ml). The mixture was stirred at ambient temperature for 3 hours, then the organic phase was separated, washed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml), dried (Na2SO4) and the solvents were removed in vacuo to give 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole as a brown solid (13.1 g) which was used without further purification.

Aufarbeitung

  1. customthe organic phase was separated
  2. washwashed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml)
  3. dry with materialdried (Na2SO4)
  4. customthe solvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6862eca620ff44419eb52980ee99c1a7
Quelldatensatz
uspto-grants-2005_05
Patentnummer
US06900216B2

Notizen zur Reaktion

Wird geladen…