Hydrazine → 1H-Pyrazolo(4,3-b)pyridine

HRID 218464

Reaktionsgleichung

Reaktionsgleichung von HRID 218464
F[C:2]1[C:3]([CH:8]=O)=[N:4][CH:5]=[CH:6][CH:7]=1.[NH2:10][NH2:11]>O>[NH:10]1[C:2]2[C:3](=[N:4][CH:5]=[CH:6][CH:7]=2)[CH:8]=[N:11]1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 113440173-Fluoro-2-pyridinecarboxaldehyde

Produkt 1

HCID 216436531H-Pyrazolo(4,3-b)pyridineAusbeute 60,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 3-fluoro-2-pyridinecarboxaldehyde (4 g, 32 mmol) and hydrazine (20.5 g) was kept at 115° C. for 7 hr, then cooled to rt. The reaction mixture was diluted with water and extracted with EtOAc. The organic phases were combined, washed with brine, and dried. Concentration followed by flash chromatography afforded 1H-pyrazolo[4,3-b]pyridine (2.3 g, 60.4%).

Aufarbeitung

  1. extractionextracted with EtOAc
  2. washwashed with brine
  3. customdried
  4. concentrationConcentration

Quellen und Nachweise

ORD-Eintrag
ord-2a2bc17e86064d979af9365c6fef2b04
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198456B2

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