Lithium hydroxide, monohydrate → 3-Chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

HRID 2184696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2184696
C([O:3][C:4]([C:6]1[NH:10][C:9]2[C:11]([Cl:14])=[CH:12][S:13][C:8]=2[CH:7]=1)=[O:5])C.O[Li].O>>[Cl:14][C:11]1[C:9]2[NH:10][C:6]([C:4]([OH:5])=[O:3])=[CH:7][C:8]=2[S:13][CH:12]=1

Komponenten

3

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 57348924Ethyl 3-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylate

Produkt 1

HCID 219068633-Chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Versuchsvorschrift

3-Chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester was hydrolyzed according to Procedure F (7 equiv LiOH—H2O; room temperature overnight, then at 50° C. overnight again; addified aqueous phase extracted with ethyl acetate; combined organic phases dried over MgSO4, concentrated).

Aufarbeitung

  1. customroom temperature overnight
  2. customat 50° C.
  3. customovernight
  4. extractionaddified aqueous phase extracted with ethyl acetate
  5. dry with materialcombined organic phases dried over MgSO4
  6. concentrationconcentrated)

Quellen und Nachweise

ORD-Eintrag
ord-15ff168d3fca4249a9e3fd07c98098dd
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06399601B1

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