1-(2-Trifluoromethoxyphenyl)piperazine → HCID 22458150, Verbindung

HRID 2184845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2184845
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>CCOCC>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[O:3][C:2]([F:1])([F:16])[F:17])[CH2:11][CH2:12]1

Komponenten

3

Edukt 1

HCID 107529251-(2-Trifluoromethoxyphenyl)piperazine

Produkt 1

HCID 22458150HCID 22458150, VerbindungAusbeute 41 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

The title compound was obtained following the procedure described for example 54, but using 1-(2-trifluoromethoxyphenyl)piperazine in place of 1-(4-nitro-2-methoxyphenyl)piperazine. The reaction mixture was heated at 120° C. for 8 h. The residue obtained by usual work-up and extraction with Et2O was purified by flash chromatography (petroleum ether-EtOAc gradient from 90:10 to 80:20) to afford the title compound. Yield: 41%.

Aufarbeitung

  1. customwas purified by flash chromatography (petroleum ether-EtOAc gradient from 90:10 to 80:20)

Quellen und Nachweise

ORD-Eintrag
ord-bb4173f860024e33ac2c23ea77378532
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06399614B1

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