Potassium Hydroxide → 2-Methoxy-3-methylbenzoic acid

HRID 2186637

Reaktionsgleichung

Reaktionsgleichung von HRID 2186637
[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+]>CO.O>[CH3:1][O:2][C:3]1[C:12]([CH3:13])=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

5

Edukt 2

HCID 14797Potassium HydroxideHCID 13229229Methyl 2-methoxy-3-methylbenzoate

Produkt 1

HCID 9523962-Methoxy-3-methylbenzoic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 2 (1.19 mol) in a mixture of methanol (2 L) and water (0.5 L), potassium hydroxide pellets (100 gram, 1.5 mol) were added under cooling. The mixture was refluxed overnight and evaporated to dryness. The residue was dissolved in water (0.5 L) and acidified with HCl 6N. The product precipitated and 189 g of product was collected as white crystals. Yield 95%. 1H NMR (500 MHz, CDCl3, 25° C.) δ: 2.234 (s, 3H, CH3), 3.717 (s, 3H, OCH3), 7.062 (t, J=7.5, 1H, ArH), 7.365 (d, J=7.5, 1H, ArH), 7.496 (d, J=7.5, 1H, ArH).

Aufarbeitung

  1. additionwere added
  2. temperatureunder cooling
  3. temperatureThe mixture was refluxed overnight
  4. customevaporated to dryness
  5. dissolutionThe residue was dissolved in water (0.5 L)
  6. customThe product precipitated
  7. custom189 g of product was collected as white crystals

Quellen und Nachweise

ORD-Eintrag
ord-dbaf181f786043bd93d9666b8a8a3bf8
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06406297B1

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