2-Nitrotoluene → Benzaldehyde

HRID 2186650

Reaktionsgleichung

Reaktionsgleichung von HRID 2186650
[Br-].C(N([P+](N(CC)CC)(N(CC)CC)N(CC)CC)CC)C.[F-:23].[K+].[N+](C1C=CC=CC=1C)([O-])=O.Cl[C:36]1[CH:43]=[CH:42][C:39]([CH:40]=[O:41])=[CH:38][CH:37]=1>CN1CCCC1=O.C1(C)C(C)=CC=CC=1>[F:23][C:36]1[CH:43]=[CH:42][C:39]([CH:40]=[O:41])=[CH:38][CH:37]=1.[CH:40](=[O:41])[C:39]1[CH:42]=[CH:43][CH:36]=[CH:37][CH:38]=1

Komponenten

8

Edukt 4

HCID 69442-NitrotolueneHCID 77264-ChlorobenzaldehydeHCID 522689Potassium FluorideHCID 11036771Tetrakis(diethylamino)phosphonium bromide

Produkt 2

HCID 240BenzaldehydeHCID 680234-Fluorobenzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7237O-XyleneLösungsmittelHCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

At 60° C., a solution of 12.0 g (0.03 mol) of tetrakis(diethylamino)phosphonium bromide in 12 g of N-methylpyrrolidone (NMP), 174.3 g (3 mol) of potassium fluoride, 4.1 g (0.03 mol) of nitrotoluene and 18 ml of xylene are successively added to 421.7 g (3 mol) of 4-chlorobenzaldehyde (4-CBAL). The reaction mixture is dried by azeotropic distillation of the xylene under reduced pressure. After 24 hours at 1 90° C., the formation of 4-fluorobenzaldehyde (4-FBAL) and of benzaldehyde produced by dehalogenation, and the conversion of the reaction are determined by gas chromatography.

Aufarbeitung

  1. dry with materialThe reaction mixture is dried by azeotropic distillation of the xylene under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-952e4b891acd47d899810b31b7163350
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06407029B1

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