Water → N-(4-aminophenyl)-2-hydroxybenzamide

HRID 2186983Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2186983
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:20])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1)(=O)C.C(=O)(O)[O-].[Na+].O.[Cl-].[Na+]>CO>[NH2:19][C:16]1[CH:15]=[CH:14][C:13]([NH:12][C:11](=[O:20])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[OH:4])=[CH:18][CH:17]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 516892Sodium BicarbonateHCID 18543278HCID 18543278, Verbindung

Produkt 1

HCID 2781453N-(4-aminophenyl)-2-hydroxybenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of 2-(4-aminophenylcarbamoyl)phenyl acetate (580 mg) in methanol (10 mL) is added saturated sodium bicarbonate (2 mL) and water (3 mL). The mixture is heated at 80° C. for 30 minutes, then poured into half-saturated aqueous sodium chloride and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oil which is then triturated with diethyl ether to provide the desired product as a white solid.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialThe ethyl acetate solution is dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto give an oil which
  5. customis then triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-829c7a4754de4f729a1088c80b9973ee
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06407123B1

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