Hydrochloric Acid → HCID 70167927, Verbindung

Reaktionsgleichung

C([CH2:8][NH:9][CH2:10][C:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[C:12]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)C1C=CC=CC=1.[ClH:28]>C(O)C.[Pd]>[ClH:28].[F:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[C@@H:12]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C@@H:11]([CH2:10][NH:9][CH3:8])[CH2:20][CH2:19]2

Komponenten

Versuchsvorschrift

To a mixture of 2-(N-benzylmethylamino)methyl-6-fluoro-1-phenyl-3,4-dihydronaphthalene (0.95 g) in ethyl alcohol (50 cm3) and hydrochloric acid (5 M, 1 cm3) was added palladium on charcoal (5%, 0.25 g). The resultant mixture was stirred under an atmosphere of hydrogen at a pressure of 2 atm at room temperature for 60 h. The catalyst was removed by filtration through a pad of Dicalite® and the solvent was evaporated under reduced pressure to provide the title compound (0.75 g) as a white solid.