Sodium Carbonate → 2-t-Butyldimethylsilyl-3-(t-butyldimethylsilyloxymethylene)-6-methoxy-7-isopropoxybenzofuran

HRID 218824Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 218824
[CH:1]([O:4][C:5]1[C:10]([O:11][CH3:12])=[CH:9][C:8](I)=[CH:7][C:6]=1[OH:14])([CH3:3])[CH3:2].[Si:15]([C:22]#[C:23][CH2:24][O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27])([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16].[Cl-].[Li+].C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[Si:15]([CH:22]1[C:23](=[CH:24][O:25][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:27])[CH3:28])[C:7]2[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:5]([O:4][CH:1]([CH3:2])[CH3:3])[C:6]=2[O:14]1)([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]

Komponenten

7

Edukt 4

HCID 10340Sodium CarbonateHCID 433294Lithium ChlorideHCID 10968062Tert-butyl(3-(tert-butyldimethylsilyl)prop-2-ynyloxy)-dimethylsilaneHCID 57421943HCID 57421943, Verbindung

Produkt 1

HCID 670422652-t-Butyldimethylsilyl-3-(t-butyldimethylsilyloxymethylene)-6-methoxy-7-isopropoxybenzofuranAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 167845palladium(II) acetateKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A suspension of 2-isopropoxy-3-methoxy-5-iodophenol (4.41 mmol), 1-(tert-butyldimethylsilyl) -3-(tert-butyldimethylsilyloxy)propyne (1.5 g, 5.28 mmol), lithium chloride (189 mg, 4.45 mmol) and sodium carbonate (2.34 g, 22.08 mmol) in dry dimethylformamide (5 mL) at 100° C. was deoxygenated 4 times by evacuation and backfilling with nitrogen. Palladium acetate (135 mg, 0.60 mmol) was added and the reaction vessel was degassed twice with nitrogen. The reaction mixture was then stirred at this temperature for 4 hours (tlc) and the solvent was removed by distillation under vacuum. The residue was dissolved in ethyl acetate (75 mL), stirred well, filtered and treated with triethylamine (5 mL). The solution was concentrated onto silica gel (10 g) and purified by flash chromatography (silica gel, eluent=hexane/diethyl ether/triethylamine; 95:5:1%) to afforded the title compound as a yellow oil (1.45 g, 96%); 1H NMR (300 MHz, CDCl3) δ 7.24(d, 1H, J=8.45 Hz), 6.88(d, 1H, J=8.47 Hz), 4.80(s, 2H, CH2), 4.73(m, 1H), 3.88(s, 3H, OMe), 1.36(d, 6H, J=6.17 Hz), 0.94(s, 9H), 0.92(s, 9H), 0.35(s, 6H), 0.12(s, 6H).

Aufarbeitung

  1. customwas deoxygenated 4 times by evacuation and backfilling with nitrogen
  2. customthe reaction vessel was degassed twice with nitrogen
  3. customthe solvent was removed by distillation under vacuum
  4. dissolutionThe residue was dissolved in ethyl acetate (75 mL)
  5. stirringstirred well
  6. filtrationfiltered
  7. additiontreated with triethylamine (5 mL)
  8. concentrationThe solution was concentrated onto silica gel (10 g)
  9. custompurified by flash chromatography (silica gel, eluent=hexane/diethyl ether/triethylamine; 95:5:1%)

Quellen und Nachweise

ORD-Eintrag
ord-643b48f3c0cf49f980c84e6e9586d440
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08198466B2

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