3,4-Dichlorobenzotrifluoride → [2-Chloro-5-(trifluoromethyl)phenyl]hydrazine

HRID 2188256Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2188256
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[Cl:8].O.[NH2:14][NH2:15]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[NH:14][NH2:15].[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([F:12])([F:11])[F:10])=[CH:3][C:2]=1[NH:14][NH2:15]

Komponenten

5

Edukt 2

HCID 94813,4-DichlorobenzotrifluorideHCID 24654Hydrazine hydrate (1:1)

Produkt 2

HCID 2060249[2-Chloro-5-(trifluoromethyl)phenyl]hydrazineHCID 2736687(2-Chloro-4-(trifluoromethyl)phenyl)hydrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

A mixture of 3,4-dichlorobenzotrifluoride (48 g), hydrazine hydrate (65 g) and pyridine (240 g) was stirred and heated at 150° C. for 6 hours in an autoclave at a pressure of 4 bar. The cooled mixture was quenched with sodium hydroxide solution and the organic layer evaporated in vacuo. The residue was dissolved in diethyl ether, washed (water) and the ether evaporated to give 2-chloro-4-trifluoromethylphenylhydrazine and 2-chloro-5-trifluoromethylphenylhydrazine as a 95/5 mixture (36 g),

Aufarbeitung

  1. customThe cooled mixture was quenched with sodium hydroxide solution
  2. customthe organic layer evaporated in vacuo
  3. dissolutionThe residue was dissolved in diethyl ether
  4. washwashed (water)
  5. customthe ether evaporated

Quellen und Nachweise

ORD-Eintrag
ord-63687c2795ab47eba8505e66b61fc6b6
Quelldatensatz
uspto-grants-2002_06
Patentnummer
US06410737B1

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