Hydrazine hydrate (1:1) → 1H-Indazole-5-carbonitrile

HRID 2189732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2189732
[C:1]([C:3]1[CH:4]=[C:5](F)[CH:6]=[C:7]([CH:10]=1)[CH:8]=O)#[N:2].O.[NH2:13][NH2:14]>>[NH:13]1[C:6]2[C:7](=[CH:10][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH:8]=[N:14]1

Komponenten

3

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 447549173-Fluoro-5-formylbenzonitrile

Produkt 1

HCID 111263841H-Indazole-5-carbonitrile

Versuchsvorschrift

5-Cyano-3-fluorobenzaldehyde (4 g, 26.8 mmol) was dissolved in hydrazine hydrate and stirred at room temperature for 18 hours. The solution was poured onto ice and the resultant solid was separated by filtration and then dried under vacuum at 60° C. to afford the title compound (1.27 g) as a pink solid. Further material was isolated from the aqueous layer. MS (ES): C8H5N3 requires 143; found 144 (MH+).

Aufarbeitung

  1. additionThe solution was poured onto ice
  2. customthe resultant solid was separated by filtration
  3. customdried under vacuum at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-fed1136edbaf4a77ab82c1c5925cf629
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324254B2

Notizen zur Reaktion

Wird geladen…