Hydroxyamine hydrochloride → HCID 178471847, Verbindung

HRID 2189779Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2189779
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2)#[N:2].C(=O)(O)[O-].[Na+].Cl.[NH2:25][OH:26]>C(O)C>[OH:26][NH:25][C:1](=[NH:2])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:7]=[CH:6]2

Komponenten

5

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 59316705Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate

Produkt 1

HCID 178471847HCID 178471847, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Ethyl 3-(5-cyano-1H-indazol-1-yl)propanoate (D47) (1 g, 4.11 mmol) was dissolved in ethanol (30 ml) and sodium bicarbonate (1.73 g, 20.55 mmol) and hydroxylamine hydrochloride (571 mg, 8.22 mmol) were added. The reaction was heated at 50° C. overnight and then allowed to cool. The reaction mixture was filtered and the residue washed with ethanol. The filtrate was evaporated to dryness in vacuo and the resultant crude title compound (1.06 g) was used the subsequent reactions.

Aufarbeitung

  1. temperatureto cool
  2. filtrationThe reaction mixture was filtered
  3. washthe residue washed with ethanol
  4. customThe filtrate was evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-88147cee73f647489fbcef919bffe2c4
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324254B2

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