4-Azidophenacyl bromide → HCID 12364738, Verbindung

HRID 2190314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190314
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[CH2:11]Br)=[CH:6][CH:5]=1)=[N+:2]=[N-:3].[NH2:14][C:15]([NH2:17])=[S:16].C([O-])(O)=O.[Na+]>CCO.O>[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=[C:15]([NH2:17])[S:16][CH:11]=2)=[CH:6][CH:5]=1)=[N+:2]=[N-:3]

Komponenten

6

Edukt 3

HCID 926274-Azidophenacyl bromideHCID 516892Sodium BicarbonateHCID 2723790Thiourea

Produkt 1

HCID 12364738HCID 12364738, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 1-(4-azidophenyl)-2-bromoethanone (1.37 g, 5.71 mmol) in EtOH (15 mL) at room temperature was added thiourea (0.476 g, 6.25 mmol). The reaction mixture was heated to 70° C. for 3 d, poured into a solution of NaHCO3 (602 mg) in water (50 mL) and stirred for 30 min. The precipitate that formed was collected by filtration, washed with water, and dried under high vacuum to give 4-(4-azidophenyl)thiazol-2-amine.

Aufarbeitung

  1. customThe precipitate that formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-84b7596d78144ce4b769948b1bd95ecc
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324396B2

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