Methanol → 2-Chloro-3-(1-cyano-1-methylethyl)benzoic acid

HRID 2190461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2190461
[Cl:1][C:2]1[C:11]([C:12]([C:15]#[N:16])([CH3:14])[CH3:13])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].CO.O>O1CCCC1>[Cl:1][C:2]1[C:11]([C:12]([C:15]#[N:16])([CH3:14])[CH3:13])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 962WaterHCID 67312408Methyl 2-chloro-3-(1-cyano-1-methylethyl)benzoate

Produkt 1

HCID 668102752-Chloro-3-(1-cyano-1-methylethyl)benzoic acidAusbeute 91,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of methyl 2-chloro-3-(1-cyano-1-methylethyl)benzoate (1.67 g, 7.02 mmol) in tetrahydrofuran (24 mL)/methanol (8 mL)/water (8 mL) was added lithium hydroxide•monohydrate (501 mg, 11.9 mmol), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and 6N hydrochloric acid (2.8 mL) was added dropwise to the residue. The precipitate was collected by filtration, and washed with water to give the title compound (1.43 g, 91%) as a white powder.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure, and 6N hydrochloric acid (2.8 mL)
  2. additionwas added dropwise to the residue
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-05268ac2ad094d22b6c37e96de2c3fe0
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08324395B2

Notizen zur Reaktion

Wird geladen…