Trifluoroacetic acid → 2-((4-(Acetamido)phenyl)amino)-4-phenethylbenzoic acid

HRID 2191851

Reaktionsgleichung

Reaktionsgleichung von HRID 2191851
FC(F)(F)C(O)=O.[C:8]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19]2[CH:31]=[C:30]([CH2:32][CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH:29]=[CH:28][C:20]=2[C:21]([O:23]C(C)(C)C)=[O:22])=[CH:14][CH:13]=1)(=[O:10])[CH3:9]>>[C:8]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([NH:18][C:19]2[CH:31]=[C:30]([CH2:32][CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH:29]=[CH:28][C:20]=2[C:21]([OH:23])=[O:22])=[CH:16][CH:17]=1)(=[O:10])[CH3:9]

Komponenten

3

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68957261Tert-butyl 2-((4-(acetamido)phenyl)amino)-4-phenethylbenzoate

Produkt 1

HCID 576680632-((4-(Acetamido)phenyl)amino)-4-phenethylbenzoic acid

Versuchsvorschrift

Trifluoroacetic acid 7.5 mL was added to the obtained tert-butyl 2-((4-(acetamido)phenyl)amino)-4-phenethylbenzoate, and it was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, methanol was added to the obtained residue, and solid matter was filtrated to give 2-((4-(acetamido)phenyl)amino)-4-phenethylbenzoic acid 23 mg of a white solid.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure, methanol
  2. additionwas added to the obtained residue, and solid matter
  3. filtrationwas filtrated

Quellen und Nachweise

ORD-Eintrag
ord-b9853af598904e009feca33baf0fa0b5
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08327467B2

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