Dimethylamine → 5-bromo-N,N-dimethyl-1,3-thiazol-2-amine

Temperatur

140 °C

To a microwave vial was added N-ethyl-N-isopropylpropan-2-amine (0.72 mL, 4.1 mmol), 2,5-dibromothiazole (1.00 g, 4.1 mmol) and dimethylamine (40% in water, 0.52 mL, 4.1 mmol) in ethanol (10 mL). The vial was sealed and stirred at 140° C. under microwave irradiation for one hour, then was concentrated and purified by MPLC (eluted with a gradient of 0-50% ethyl acetate in hexanes) to yield the product as a white, crystalline solid (0.25 g, 29%).

1. customThe vial was sealed
2. concentrationwas concentrated
3. custompurified by MPLC (
4. washeluted with a gradient of 0-50% ethyl acetate in hexanes)

ORD-Eintrag

ord-612a907fbb4241d9bd97dde4493fa1d3

Quelldatensatz

uspto-grants-2012_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08198448B2