Hydrochloric Acid → 3-(Pent-2-en-3-yl)-2,2'-bitiophene

HRID 2193808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2193808
[S:1]1[CH:5]=[CH:4][C:3]([C:6](O)([CH2:9][CH3:10])[CH2:7][CH3:8])=[C:2]1[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1.Cl>C(O)(=O)C>[CH3:8][CH:7]=[C:6]([C:3]1[CH:4]=[CH:5][S:1][C:2]=1[C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)[CH2:9][CH3:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 498402833-(2,2'-Bithiophene-3-yl)pentan-3-ol

Produkt 1

HCID 679963483-(Pent-2-en-3-yl)-2,2'-bitiophene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

3-(2,2′-bithiophene-3-yl)pentan-3-ol (IIa) (0.100 g, 0.40 mmol) was dissolved in acetic acid (69 mL). A solution of concentrated HCl (0.28 mL) in acetic acid (15 mL) was added via syringe to the reaction mixture. The solution was refluxed for 4 h followed by an extraction with chloroform, washing and drying over MgSO4. The solvent was removed in vacuo. The residue was purified by column chromatography on silica (n-Hexane). (0.070 g, 75%).

Aufarbeitung

  1. temperatureThe solution was refluxed for 4 h
  2. extractionfollowed by an extraction with chloroform
  3. washwashing
  4. dry with materialdrying over MgSO4
  5. customThe solvent was removed in vacuo
  6. customThe residue was purified by column chromatography on silica (n-Hexane)

Quellen und Nachweise

ORD-Eintrag
ord-c408fb10b8f3415da4b6d5c154bfe0f1
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329923B2

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