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Water → HCID 67138479, Verbindung

HRID 2194311
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2194311
BrC[C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[C:13](=[O:16])([O-])[O-].[K+].[K+].[CH3:19]N(C)C=O.[CH3:24][C:25]1O[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:55]3[CH:54]=[CH:53][CH:52]=[C:51](O)[C:50]=3[C:49]3[C:44]2=[CH:45][CH:46]=[CH:47][CH:48]=3)=[CH:40][C:39]=1[O:59][CH3:60].[OH2:61]>>[CH3:24][C:25]1[O:61][C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:27][C:26]=1[CH2:36][O:37][C:38]1[CH:58]=[CH:57][C:41]([CH2:42][N:43]2[C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][C:49]=3[C:50]3[C:55]2=[CH:54][CH:53]=[CH:52][C:51]=3[O:16][CH2:13][C:11]2[CH:12]=[CH:3][C:4]([C:5]([O:7][CH2:8][CH3:19])=[O:6])=[CH:9][CH:10]=2)=[CH:40][C:39]=1[O:59][CH3:60]
KomponentenReaktionsbedingungenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 5

HCID 962WaterHCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 2734813Methyl 2-(bromomethyl)benzoateHCID 59571732HCID 59571732, Verbindung

Produkt 1

HCID 67138479HCID 67138479, Verbindung

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

47 mg of methyl 2-bromomethylbenzoate and 27 mg of potassium carbonate (powder) were added to N,N-dimethylformamide (2 mL) solution of 98 mg of 9-{4-[(5-methyl-2-phenyloxazole-4-yl)methoxy]-3-methoxybenzyl}-9H-carbazole-4-o 1, and stirred at 90° C. for 1 hour. After the reaction mixture was allowed to cool, water was added thereto, and then extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, the residue was crystallized from a small amount of ethanol, isolated by filtration with n-hexane, dried under a reduced pressure, and 110 mg of the subject compound was prepared.

Aufarbeitung

  1. temperatureto cool
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationAfter filtration
  6. concentrationthe filtrate was concentrated in vacuo
  7. customthe residue was crystallized from a small amount of ethanol
  8. customisolated by filtration with n-hexane
  9. dry with materialdried under a reduced pressure, and 110 mg of the subject compound
  10. customwas prepared

Quellen und Nachweise

ORD-Eintrag
ord-8cb8cbd342e44d839e2d0839295afb53
Quelldatensatz
uspto-grants-2012_12
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08329913B2

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