1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester → Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione

HRID 2194360Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2194360
C[O:2][C:3]([CH:5]1[CH2:9][CH2:8][C:7](=[O:10])[N:6]1[CH2:11][C:12]#[N:13])=O>CO.O=[Pt]=O>[C:3]1(=[O:2])[NH:13][CH2:12][CH2:11][N:6]2[C:7](=[O:10])[CH2:8][CH:9]=[C:5]12

Komponenten

4

Edukt 1

HCID 866498781-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

Produkt 1

HCID 66867679Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dioneAusbeute 63,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (1.1 g, 6.04 mmol) was dissolved in MeOH (30 ml) and hydrogenated over PtO2 (200 mg) at 20 psi for 24 hours. After filtration of the catalyst, the solvent was removed under vacuum and the residue triturated with iPrOH to afford the title compound as a white powder (580 mg, 62% yield).

Aufarbeitung

  1. filtrationAfter filtration of the catalyst
  2. customthe solvent was removed under vacuum
  3. customthe residue triturated with iPrOH

Quellen und Nachweise

ORD-Eintrag
ord-a6b0968dc79a478b84af28cbee335112
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08334286B2

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