Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride (1:1) → 2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

HRID 219486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 219486
[CH3:1][N:2]([CH2:4][CH:5]1[C:10]([OH:19])([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:3].Cl>O>[CH3:3][N:2]([CH2:4][CH:5]1[C:10]([OH:19])([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:1]

Komponenten

3

Edukt 1

HCID 9971980Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, hydrochloride (1:1)

Produkt 1

HCID 55232-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

The Tramadol Resin Complex was prepared by first dissolving 500 g of tramadol HCl in 8 liters of purified water, and then slowly adding 1,345 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D polymer (467 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convection oven to the moisture content around 20%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

Aufarbeitung

  1. additionslowly adding 1,345 g of AMBERLITE™
  2. additionThe dispersion was mixed for 4 hours and upon completion
  3. custombefore decanting the supernatant
  4. customThe wet resin complex was then dried in a VWR™ convection oven
  5. additionKOLLICOAT™ SR-30D polymer (467 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
  6. customto form a uniform mass
  7. customThe wet mass was again dried in a 50° C
  8. customThe semi-dried granules were then milled through a 40 mesh screen
  9. customcontinued drying under 50° C. until the moisture content
  10. customThe dried granules were then milled through a 40 mesh screen

Quellen und Nachweise

ORD-Eintrag
ord-aa63ecade64345a090275a9ff374f6d6
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08202537B2

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