Triethylamine → 4-(2-Ethoxybenzamido)-1-methyl-3-propylpyrazole-5-carboxamide

HRID 21949

Reaktionsgleichung

Reaktionsgleichung von HRID 21949
[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7])[CH3:2].[NH2:13][C:14]1[C:15]([CH2:23][CH2:24][CH3:25])=[N:16][N:17]([CH3:22])[C:18]=1[C:19]([NH2:21])=[O:20].C(N(CC)CC)C>ClCCl.CN(C)C1C=CN=CC=1>[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([NH:13][C:14]1[C:15]([CH2:23][CH2:24][CH3:25])=[N:16][N:17]([CH3:22])[C:18]=1[C:19]([NH2:21])=[O:20])=[O:7])[CH3:2]

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 30163972-Ethoxybenzoyl chlorideHCID 33380444-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

Produkt 1

HCID 8501354-(2-Ethoxybenzamido)-1-methyl-3-propylpyrazole-5-carboxamideAusbeute 40,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of 2-ethoxybenzoyl chloride (6.1 g, 33.0 mmol) in dichloromethane (50 ml) was added to a stirred solution of 4-amino-1-methyl-3-n-propylpyrazole-5-carboxamide (3.0 g, 16.4 mmol), 4-dimethylaminopyridine (0.02 g, 0.164 mmol) and triethylamine (3.34 g, 33.0 mmol) in dichloromethane (50 ml) at 0° C. The resulting mixture was allowed to warm to room temperature and stirred for a further 2 hours. The solvent was evaporated under vacuum, the residue dissolved in a 19:1 mixture of dichloromethane and methanol (250 ml), and then the solution washed with 1N hydrochloric acid (100 ml), dried (MgSO4) and evaporated under vacuum. The crude material was chromatographed on silica gel (200 g), eluting with a 97:3 mixture of dichloromethane and methanol, to give a pink solid; crystallisation from ethyl acetate-hexane gave the pyrazole-5-carboxamide as a pale pink solid (2.2 g, 40%), m.p. 153°-155° C. Found: C,61.66; H,6.77; N,16.95. C17H22N4O3 requires C,61.80; H,6.71; N,16.96%.

Aufarbeitung

  1. customThe solvent was evaporated under vacuum
  2. dissolutionthe residue dissolved in a 19:1 mixture of dichloromethane and methanol (250 ml)
  3. washthe solution washed with 1N hydrochloric acid (100 ml)
  4. dry with materialdried (MgSO4)
  5. customevaporated under vacuum
  6. customThe crude material was chromatographed on silica gel (200 g)
  7. washeluting with a 97:3 mixture of dichloromethane and methanol
  8. customto give a pink solid
  9. customcrystallisation from ethyl acetate-hexane

Quellen und Nachweise

ORD-Eintrag
ord-4999417e4e2e4bd6b7bbf1c5b481875b
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05426107

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