Water → 3-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one

HRID 2197434Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2197434
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2(O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH2:19]CC.[NH3:23].C(O)C.O>C(Cl)Cl>[NH2:23][C:5]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])[C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[NH:7][C:6]1=[O:11]

Komponenten

5

Edukt 3

HCID 962WaterHCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 574664415-Chloro-3-hydroxy-3-(2-propoxyphenyl)-indole-2-one

Produkt 1

HCID 219254143-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10 g (32.45 mmol) of the intermediate product 2a were suspended in 100 ml methylene chloride. After the addition of 100 ml 2-molar ethanol ammonia solution, the reaction mixture was stirred for 16 h. After this, everything was poured on to icy water and the organic phase was separated. The aqueous phase was cooled, wherein a white crystallizate formed, which was isolated. 5.7 g of the product were obtained.

Aufarbeitung

  1. customthe organic phase was separated
  2. temperatureThe aqueous phase was cooled, wherein a white crystallizate
  3. customformed
  4. customwhich was isolated

Quellen und Nachweise

ORD-Eintrag
ord-415ab69707b646358d578f706e879008
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08338590B2

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