Methanol → HCID 12249281, Verbindung

HRID 2198818Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2198818
[O:1]=[C:2]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:14][C:15]([OH:17])=[O:16].S(=O)(=O)(O)O.[OH-].[Na+].[CH3:25]O>[O-]S([O-])(=O)=O.[Na+].[Na+]>[CH3:25][O:16][C:15](=[O:17])[CH2:14][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:2]1=[O:1]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 317519Cyclododecaneaceticacid, 2-oxo-

Produkt 1

HCID 12249281HCID 12249281, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24436Sodium SulfateKatalysator

Versuchsvorschrift

One hundred seventy-five grams (0.73 mol) of the ketomono acid from step 3 and 440 ml of methanol were refluxed with agitation for 3 hours with the addition of 7.3 gm of concentrated sulfuric acid. The cooled solution was neutralized with 50% sodium hydroxide solution and then methanol and water were completely removed. The residue contained, in addition to small amounts of salt (approximately 10 gm of Na2SO4), approximately 180 gm of ketomonoester (IX) (97% yield), which was further reacted in that form.

Aufarbeitung

  1. custommethanol and water were completely removed

Quellen und Nachweise

ORD-Eintrag
ord-f87eedfd9ec7431e8d515adf77301e2b
Quelldatensatz
uspto-grants-1982_11
Patentnummer
US04360468

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