Hydroxylamine → HCID 178480898, Verbindung

HRID 2199682Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2199682
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]#[N:10])[CH2:4][CH2:3]1.[NH2:11][OH:12]>C(O)C>[OH:12][NH:11][C:9](=[NH:10])[CH2:8][N:5]1[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]1

Komponenten

4

Edukt 2

HCID 787HydroxylamineHCID 10582860(4-Methylpiperazin-1-yl)acetonitrile

Produkt 1

HCID 178480898HCID 178480898, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture (4-methylpiperazin-1-yl)acetonitrile (400 mg), hydroxylamine (50% aqueous solution, 2.0 mL) and ethanol (10.0 mL), was stirred at room temperature for 18 hours. The reaction mixture was evaporated to dryness to give a crystalline solid that was washed with hexane and dried under vacuum to give N-hydroxy-2-(4-methylpiperazin-1-yl)ethanimidamide (405 mg). 1H-NMR (400 MHz; CDCl3): 5.19 (br s, 3H), 3.00 (s, 2H), 2.75-2.28 (br m, 8H), 2.70 (s, 3H).

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness
  2. customto give a crystalline solid
  3. washthat was washed with hexane
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-5d5da70fa7a8433298b173c27da77fa8
Quelldatensatz
uspto-grants-2016_06
Patentnummer
US09359332B2

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